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Article

Mutational analysis of TAC3 and TACR3 genes in patients with idiopathic central pubertal disorders.

Arquivos brasileiros de endocrinologia e metabologia - 1 Dec 2012

Tusset Cintia, Noel Sekoni D, Trarbach Ericka B, Silveira Letícia F G, Jorge Alexander A L, Brito Vinicius N, Cukier Priscila, Seminara Stephanie B, Mendonça Berenice B de, Kaiser Ursula B, Latronico Ana Claudia

Abstract excerpt

OBJECTIVE: To investigate the presence of variants in the TAC3 and TACR3 genes, which encode NKB and its receptor (NK3R), respectively, in a large cohort of patients with idiopathic central pubertal disorders. SUBJECTS AND METHODS: Two hundred and thirty seven patients were studied: 114 with central precocious puberty (CPP), 73 with normosmic isolated hypogonadotropic hypogonadism (IHH), and 50 with...

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Source

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Identifiers

PMID: 23329188
DOI: 10.1590/s0004-27302012000900008
PMCID: PMC3712828

Genes

TACR3
TAC3
IHH

Variants

Provenance

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