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Article

An update on the genetic causes of central precocious puberty

1 Jan 2016

Abstract excerpt

Central precocious puberty (CPP) is caused by the premature reactivation of the hypothalamic-pituitary-gonadal axis. Genetic, nutritional, and environmental factors play a crucial role in determining pubertal timing. Recently mutations in kisspeptin (KISS1), kisspeptin receptor (KISS1R), and makorin RING finger protein 3 (MKRN3) genes have been identified as genetic causes of CPP. In particular, the MKRN3 gene is...

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PMID: 27462581
DOI: 10.6065/apem.2016.21.2.66

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