Article
Mutational analysis of TAC and TACR3 in idiopathic central precocious puberty.
Prilozi (Makedonska akademija na naukite i umetnostite. Oddelenie za medicinski nauki) - 1 Jan 2014
Krstevska-Konstantinova Marina, Tasic Velibor B, Montenegro Luciana Ribeiro, Dervisov Donco, Beneduzzi Daiane, Gontijo Silveira Leticia F, Gucev Zoran S
Abstract excerpt
BACKGROUND: The genetic background of idiopathic central precocious puberty (ICPP) is not well understood, and is thought to arise from the effect of multiple genes. Familial ICPP have been reported suggesting the existence of monogenic causes of ICPP. The neurokinin B (NKB) system has recently been implicated in the regulation of the human reproductive axis. In humans, NKB and its receptor are encoded by the...
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