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Exercise Prevents Maternal High-Fat Diet–Induced Hypermethylation of the <i>Pgc-1α</i> Gene and Age-Dependent Metabolic Dysfunction in the Offspring

16 Jan 2014

Abstract excerpt

Abnormal conditions during early development adversely affect later health. We investigated whether maternal exercise could protect offspring from adverse effects of a maternal high-fat diet (HFD) with a focus on the metabolic outcomes and epigenetic regulation of the metabolic master regulator, peroxisome proliferator-activated receptor γ coactivator-1α (Pgc-1α). Female C57BL/6 mice were exposed to normal chow,...

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PMID: 24430439
DOI: 10.2337/db13-1614

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