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Gene Expression and DNA Methylation of <i>PPARGC1A</i> in Muscle and Adipose Tissue From Adult Offspring of Women With Diabetes in Pregnancy

7 Jul 2016

Abstract excerpt

Prenatal exposure to maternal hyperglycemia is associated with an increased risk of later adverse metabolic health. Changes in the regulation of peroxisome proliferator-activated receptor-γ coactivator-1α (PPARGC1A) in skeletal muscle and subcutaneous adipose tissue (SAT) is suggested to play a role in the developmental programming of dysmetabolism based on studies of human subjects exposed to an abnormal...

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PMID: 27388218
DOI: 10.2337/db16-0227

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