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The effects of paternal high-fat diet exposure on offspring metabolism with epigenetic changes in the mouse <i>adiponectin</i> and <i>leptin</i> gene promoters

31 May 2016

Abstract excerpt

Recent studies have demonstrated that epigenetic changes resulting from malnutrition might play important roles in transgenerational links with metabolic diseases. Previously, we observed that exposure to a high-fat diet (HFD) in utero caused a metabolic syndrome-like phenomenon through epigenetic modifications of the adiponectin and leptin genes that persisted for multiple generations. Recent etiological studies...

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PMID: 27245335
DOI: 10.1152/ajpendo.00095.2016

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