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Article

Low HERV-K(C4) copy number is associated with type 1 diabetes.

Diabetes - 1 May 2014

Mason Mike J, Speake Cate, Gersuk Vivian H, Nguyen Quynh-Anh, O'Brien Kimberly K, Odegard Jared M, Buckner Jane H, Greenbaum Carla J, Chaussabel Damien, Nepom Gerald T

Abstract excerpt

Complement component C4 (C4) is a highly variable complement pathway gene situated ∼500 kb from DRB1 and DQB1, the genes most strongly associated with many autoimmune diseases. Variations in C4 copy number (CN), length, and isotype create a highly diverse gene cluster in which insertion of an endogenous retrovirus in the ninth intron of C4, termed HERV-K(C4), is a notable component. We investigated the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 24430436
DOI: 10.2337/db13-1382

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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