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Article

The variable endogenous retroviral insertion in the human complement C4 gene: a transmission study in type I diabetes mellitus.

Human immunology - 1 Jun 2002

Pani Michael A, Wood Jeffrey P, Bieda Katrin, Toenjes Ralf R, Usadel Klaus H, Badenhoop Klaus

Abstract excerpt

A variable endogenous retroviral element has been identified in intron 9 of the complement C4 gene [HERV-K(C4)], which maps to the class III region of the major histocompatibility complex (MHC) on chromosome 6p21.3. Genetic susceptibility to type I diabetes is mainly conferred by the MHC locus and the complement C4 region has been implied to contribute to human leukocyte antigen DQ (HLA-DQ) mediated disease risk....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 12039523
DOI: 10.1016/s0198-8859(02)00398-1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The variable endogenous retroviral insertion in the human complement C4 gene: a transmission study in type I diabetes mellitus.PMID 12039523Read ↗

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