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Article

Low C4, C4A and C4B gene copy numbers are stronger risk factors for juvenile-onset than for adult-onset systemic lupus erythematosus.

Rheumatology (Oxford, England) - 1 May 2016

Pereira Kaline M C, Faria Atila G A, Liphaus Bernadete L, Jesus Adriana A, Silva Clovis A, Carneiro-Sampaio Magda, Andrade Luis E C

Abstract excerpt

OBJECTIVE: Complete deficiency of Complement C4 component is a strong genetic risk factor for SLE. C4 is encoded by two different genes, C4A and C4B, which show considerable gene copy number (GCN) variation. This study investigates the association of total C4, C4A and C4B GCN with JSLE. METHODS: Ninety JSLE patients, 170 adult-onset SLE (aSLE) patients and 200 healthy individuals were evaluated for C4A and C4B...

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PMID: 26800705
DOI: 10.1093/rheumatology/kev436

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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