Article
The dichotomous size variation of human complement C4 genes is mediated by a novel family of endogenous retroviruses, which also establishes species-specific genomic patterns among Old World primates.
Immunogenetics - 1 Jan 1994
Dangel A W, Mendoza A R, Baker B J, Daniel C M, Carroll M C, Wu L C, Yu C Y
Abstract excerpt
The human complement C4 genes in the HLA exhibit an unusual, dichotomous size polymorphism and a four-gene, modular variation involving novel gene RP, complement C4, steroid 21-hydroxylase (CYP21), and tenascin-like Gene X (RCCX). The C4 gene size dichotomy is mediated by an endogenous retrovirus...
Topics
- Amino Acid Sequence
- Animals
- Base Sequence
- Cercopithecidae
- Complement C4
- DNA
- DNA, Viral
- Genetic Variation
- Genome, Human
- Humans
- Introns
- Molecular Sequence Data
- Mutation
- Recombination, Genetic