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Mitochondrial genome variations in advanced stage breast cancer: a case-control study.

Mitochondrion - 1 Jul 2013

Tipirisetti Nageswara Rao, Lakshmi Rao K, Govatati Suresh, Govatati Sowdamani, Vuree Sugunakar, Singh Lalji, Raghunadha Rao Digumarti, Bhanoori Manjula, Vishnupriya Satti

Abstract excerpt

Entire mitochondrial DNA (mtDNA) sequencing was carried out in 101 primary breast cancer patients and 90 controls of south Indian origin. We identified 69 novel mutations in breast cancer patients and 637 reported polymorphisms in patients and/or controls. PolyPhen-2 analysis predicted 5 out of 14 novel missense mutations as 'probably damaging variants'. Haplogrouping analysis identified a significant association...

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PMID: 23628690
DOI: 10.1016/j.mito.2013.04.010

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