Article
Motor and cognitive deficits in aged tau knockout mice in two background strains.
Molecular neurodegeneration - 14 Aug 2014
Lei Peng, Ayton Scott, Moon Steve, Zhang Qihao, Volitakis Irene, Finkelstein David I, Bush Ashley I
Abstract excerpt
BACKGROUND: We recently reported that Parkinsonian and dementia phenotypes emerge between 7-12 months of age in tau-/- mice on a Bl6/129sv mixed background. These observations were partially replicated by another group using pure Bl6 background tau-/- mice, but notably they did not observe a cognitive phenotype. A third group using Bl6 background tau-/- mice found cognitive impairment at 20-months of age....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.