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Article

Zonular defects in loxl1-deficient zebrafish.

Clinical & experimental ophthalmology - 1 Jan 2022

Zhang Min, Sun Shaoyang, Wang Lei, Wang Xu, Chen Tianhui, Chen Zexu, Jiang Yongxiang

Abstract excerpt

BACKGROUND: To investigate the roles of the lysyl oxidase-like 1 (loxl1) gene in zebrafish eye development and the potency of loxl1 deficiency in mimicking the ocular manifestations of exfoliation syndrome (XFS). METHODS: CRISPR/Cas9 technology was used to generate a frameshift coding deletion in zebrafish loxl1. Expression profiles and ocular manifestations of the wildtype, heterozygous mutant (loxl1+/- ) and...

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Identifiers

PMID: 34585825
DOI: 10.1111/ceo.14017

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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