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Article

Autocrine IGF-1 action in adipocytes controls systemic IGF-1 concentrations and growth.

Diabetes - 1 Aug 2008

Klöting Nora, Koch Linda, Wunderlich Thomas, Kern Matthias, Ruschke Karen, Krone Wilhelm, Brüning Jens C, Blüher Matthias

Abstract excerpt

OBJECTIVE: IGF-1 and the IGF-1 receptor (IGF-1R) have been implicated in the regulation of adipocyte differentiation and lipid accumulation in vitro. RESEARCH DESIGN AND METHODS: To investigate the role of IGF-1 receptor in vivo, we have inactivated the Igf-1r gene in adipose tissue (IGF-1R(aP2Cre) mice) using conditional gene targeting strategies. RESULTS: Conditional IGF-1R inactivation resulted in increased...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Receptor, IGF Type 1

Source

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Identifiers

PMID: 18443199
DOI: 10.2337/db07-1538
PMCID: PMC2494689

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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