Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

IGF-binding protein-2 protects against the development of obesity and insulin resistance.

Diabetes - 1 Feb 2007

Wheatcroft Stephen B, Kearney Mark T, Shah Ajay M, Ezzat Vivienne A, Miell John R, Modo Michael, Williams Stephen C R, Cawthorn Will P, Medina-Gomez Gema, Vidal-Puig Antonio, Sethi Jaswinder K, Crossey Paul A

Abstract excerpt

Proliferation of adipocyte precursors and their differentiation into mature adipocytes contributes to the development of obesity in mammals. IGF-I is a potent mitogen and important stimulus for adipocyte differentiation. The biological actions of IGFs are closely regulated by a family of IGF-binding proteins (IGFBPs), which exert predominantly inhibitory effects. IGFBP-2 is the principal binding protein secreted...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to 3T3-L1 Cells
Share to Adipocytes

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Adiposity

Share to Fatty Liver

Share to Insulin-Like Growth Factor I

Share to Insulin Resistance

Share to Leptin

Share to Thinness

Source

Open in PubMed Open full text

Identifiers

PMID: 17259371
DOI: 10.2337/db06-0436
PMCID: PMC4295171

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

IGF-binding protein-2 protects against the development of obesity and insulin resistance.PMID 17259371Read ↗

The heparin-binding domains of IGFBP-2 mediate its inhibitory effect on preadipocyte differentiation and fat development in male mice.Semantic proximity Read ↗

Insulin-like Growth Factor 2 mRNA-Binding Protein 2—a Potential Link Between Type 2 Diabetes Mellitus and CancerSemantic proximity Read ↗

Insulin-like growth factor II (IGF-II).Semantic proximity Read ↗

IGFBP4 Is Required for Adipogenesis and Influences the Distribution of Adipose Depots.Semantic proximity Read ↗

The Relationship of Insulin-Like Growth Factor 2 to Fetal Growth and AdipositySemantic proximity Read ↗

Autocrine IGF-1 action in adipocytes controls systemic IGF-1 concentrations and growth.Semantic proximity Read ↗

IGFBP2 is neither sufficient nor necessary for the physiological actions of leptin on glucose homeostasis in male ob/ob mice.Semantic proximity Read ↗

Transgenic mouse models for studying the functions of insulin-like growth factor-binding proteins.Semantic proximity Read ↗

Insulin and agingSemantic proximity Read ↗

Gene-targeting and transgenic approaches to IGF and IGF binding protein functionSemantic proximity Read ↗

Class 2 IGF-1 isoforms are dispensable for viability, growth and maintenance of IGF-1 serum levels.Semantic proximity Read ↗

Recent Insights into Insulin-Like Growth Factor Binding Protein 2 Transcriptional RegulationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.