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Article

Development of novel potent orally bioavailable oseltamivir derivatives active against resistant influenza A.

Journal of medicinal chemistry - 13 Feb 2014

Schade Dennis, Kotthaus Joscha, Riebling Lukas, Kotthaus Jürke, Müller-Fielitz Helge, Raasch Walter, Koch Oliver, Seidel Nora, Schmidtke Michaela, Clement Bernd

Abstract excerpt

With the emergence of oseltamivir-resistant influenza viruses and in view of a highly pathogenic flu pandemic, it is important to develop new anti-influenza agents. Here, the development of neuraminidase (NA) inhibitors that were designed to overcome resistance mechanisms along with unfavorable pharmacokinetic (PK) properties is described. Several 5-guanidino- and 5-amidino-based oseltamivir derivatives were...

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Identifiers

PMID: 24422530
DOI: 10.1021/jm401492x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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