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Article

Drug Repurposing Identifies Inhibitors of Oseltamivir-Resistant Influenza Viruses.

Angewandte Chemie (International ed. in English) - 1 Mar 2016

Bao Ju, Marathe Bindumadhav, Govorkova Elena A, Zheng Jie J

Abstract excerpt

The neuraminidase (NA) inhibitor, oseltamivir, is a widely used anti-influenza drug. However, oseltamivir-resistant H1N1 influenza viruses carrying the H275Y NA mutation spontaneously emerged as a result of natural genetic drift and drug treatment. Because H275Y and other potential mutations may generate a future pandemic influenza strain that is oseltamivir-resistant, alternative therapy options are needed....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 26833677
DOI: 10.1002/anie.201511361
PMCID: PMC4807618

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