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Article

Oseltamivir analogues bearing N-substituted guanidines as potent neuraminidase inhibitors.

Journal of medicinal chemistry - 10 Apr 2014

Mooney Caitlin A, Johnson Stuart A, 't Hart Peter, Quarles van Ufford Linda, de Haan Cornelis A M, Moret Ed E, Martin Nathaniel I

Abstract excerpt

A series of oseltamivir analogues bearing an N-substituted guanidine unit were prepared and evaluated as inhibitors of neuraminidases from four strains of influenza. The two most potent analogues identified contain relatively small N-guanidine substituents (N-methyl and N-hydroxyl) and display en...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 24649802
DOI: 10.1021/jm401977j

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24649802-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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