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Article

Discovery of hydrazide-containing oseltamivir analogues as potent inhibitors of influenza A neuraminidase.

European journal of medicinal chemistry - 5 Oct 2021

Zhao Hongqian, Jiang Siyuan, Ye Zhifan, Zhu Hongxi, Hu Baichun, Meng Peipei, Hu Yanmei, Zhang Huicong, Wang Kuanglei, Wang Jun, Tian Yongshou

Abstract excerpt

Neuraminidase (NA) inhibitors play a prime role in treating influenza. However, a variety of viruses containing mutant NAs have developed severe drug resistance towards NA inhibitors, so it is of crucial significance to solve this problem. Encouraged by urea-containing compound 12 disclosed by our lab, we designed a series of oseltamivir derivatives bearing hydrazide fragment for targeting the 150 cavity. Among...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34082224
DOI: 10.1016/j.ejmech.2021.113567

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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