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Article

Discovery of acylguanidine oseltamivir carboxylate derivatives as potent neuraminidase inhibitors.

Bioorganic & medicinal chemistry - 15 May 2017

Li Zhaoliang, Meng Yanchun, Xu Shengtao, Shen Wang, Meng Zhaoqing, Wang Zhenzhong, Ding Gang, Huang Wenzhe, Xiao Wei, Xu Jinyi

Abstract excerpt

In search of novel anti-influenza agents with higher potency, a series of acylguanidine oseltamivir carboxylate analogues were synthesized and evaluated against influenza viruses (H1N1 and H3N2) in vitro. The representative compounds with strong inhibitory activities (IC50 <40nM) against neuraminidase (NA) were further tested against the NA from oseltamivir-resistant strain (H259Y). Among them, compounds 9 and 17...

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Identifiers

PMID: 28385598
DOI: 10.1016/j.bmc.2017.03.052

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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