Novel Neuraminidase Inhibitors: Identification, Biological Evaluation and Investigations of the Binding Mode

Abstract excerpt

BACKGROUND: The pathogenicity of influenza A and B viruses depends on the function of influenza neuraminidase (NA). Emerging resistant influenza A viruses of subtype H1N1 increasingly challenge the effectiveness of established NA inhibitors. Recent computational studies have indicated several weak points of NA that can be exploited for rational inhibitor design to conquer this imminent threat, such as the opening...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Bioactive natural compounds
• Share to Influenza Virus Research Studies
• Share to Quinazolinone synthesis and applications