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Article

Functional genetic variants of GEN1 predict overall survival of Chinese epithelial ovarian cancer patients.

Journal of translational medicine - 18 Jun 2024

Li Haoran, Wu Jiao, Xu Qing, Pang Yangyang, Gu Yanzi, Wang Mengyun, Cheng Xi

Abstract excerpt

BACKGROUND: Inherited variations in DNA double-strand break (DSB) repair pathway are known to influence ovarian cancer occurrence, progression and treatment response. Despite its significance, survival-associated genetic variants within the DSB pathway remain underexplored. METHODS: In the present study, we performed a two-phase analysis of 19,290 single-nucleotide polymorphisms (SNPs) in 199 genes in the DSB...

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Identifiers

PMID: 38890669
DOI: 10.1186/s12967-024-05236-1
PMCID: PMC11184878

Genes

GEN1

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