Article
PD1 gene polymorphism is associated with a poor prognosis in hepatocellular carcinoma following liver resection, cohort study.
International journal of surgery (London, England) - 1 Aug 2020
Yamamoto Masateru, Kobayashi Tsuyoshi, Mashima Hiroaki, Miki Daiki, Kuroda Shintaro, Hamaoka Michinori, Aikata Hiroshi, Chayama Kazuaki, Ohdan Hideki
Abstract excerpt
BACKGROUND: This study examined whether single nucleotide polymorphism (SNP) in programmed cell death protein (PD)-1 is related to the postoperative prognosis of patients with hepatocellular carcinoma (HCC). The immune checkpoint protein PD-1 is an important inhibitor of T cell responses. SNP in the promoter region of PD-1 -606 G/A has been reported to result in high activation and expression of PD-1 associated...
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