Article
Candidate luminal B breast cancer genes identified by genome, gene expression and DNA methylation profiling.
PloS one - 1 Jan 2014
Cornen Stéphanie, Guille Arnaud, Adélaïde José, Addou-Klouche Lynda, Finetti Pascal, Saade Marie-Rose, Manai Marwa, Carbuccia Nadine, Bekhouche Ismahane, Letessier Anne, Raynaud Stéphane, Charafe-Jauffret Emmanuelle, Jacquemier Jocelyne, Spicuglia Salvatore, de The Hugues, Viens Patrice, Bertucci François, Birnbaum Daniel, Chaffanet Max
Abstract excerpt
Breast cancers (BCs) of the luminal B subtype are estrogen receptor-positive (ER+), highly proliferative, resistant to standard therapies and have a poor prognosis. To better understand this subtype we compared DNA copy number aberrations (CNAs), DNA promoter methylation, gene expression profiles, and somatic mutations in nine selected genes, in 32 luminal B tumors with those observed in 156 BCs of the other...
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