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Article

Resurrecting the ancestral steroid receptor: ancient origin of estrogen signaling.

Science (New York, N.Y.) - 19 Sept 2003

Thornton Joseph W, Need Eleanor, Crews David

Abstract excerpt

Receptors for sex and adrenal steroid hormones are absent from fully sequenced invertebrate genomes and have not been recovered from other invertebrates. Here we report the isolation of an estrogen receptor ortholog from the mollusk Aplysia californica and the reconstruction, synthesis, and experimental characterization of functional domains of the ancestral protein from which all extant steroid receptors (SRs)...

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Identifiers

PMID: 14500980
DOI: 10.1126/science.1086185

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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