Article
Adaptive evolution: evaluating empirical support for theoretical predictions.
Nature reviews. Genetics - 1 Dec 2012
Olson-Manning Carrie F, Wagner Maggie R, Mitchell-Olds Thomas
Abstract excerpt
Adaptive evolution is shaped by the interaction of population genetics, natural selection and underlying network and biochemical constraints. Variation created by mutation, the raw material for evolutionary change, is translated into phenotypes by flux through metabolic pathways and by the topography and dynamics of molecular networks. Finally, the retention of genetic variation and the efficacy of selection...
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