Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Parallel genetic changes and nonparallel gene-environment interactions characterize the evolution of drug resistance in yeast.

Genetics - 1 Sept 2012

Gerstein Aleeza C, Lo Dara S, Otto Sarah P

Abstract excerpt

Beneficial mutations are required for adaptation to novel environments, yet the range of mutational pathways that are available to a population has been poorly characterized, particularly in eukaryotes. We assessed the genetic changes of the first mutations acquired during adaptation to a novel environment (exposure to the fungicide, nystatin) in 35 haploid lines of Saccharomyces cerevisiae. Through whole-genome...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adaptation, Physiological
Share to Drug Resistance, Fungal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Evolution, Molecular

Share to Gene-Environment Interaction

Share to Genes, Fungal

Share to Mutation

Share to Saccharomyces cerevisiae

Share to Stress, Physiological

Source

Open in PubMed Open full text

Identifiers

PMID: 22714405
DOI: 10.1534/genetics.112.142620
PMCID: PMC3430539

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Parallel genetic changes and nonparallel gene-environment interactions characterize the evolution of drug resistance in yeast.PMID 22714405Read ↗

The loci of environmental adaptation in a model eukaryote.Semantic proximity Read ↗

Molecular specificity, convergence and constraint shape adaptive evolution in nutrient-poor environments.Semantic proximity Read ↗

Challenges and potential solutions for studying the genetic and phenotypic architecture of adaptation in microbes.Semantic proximity Read ↗

Network-Based Identification of Adaptive Pathways in Evolved Ethanol-Tolerant Bacterial Populations.Semantic proximity Read ↗

Altered access to beneficial mutations slows adaptation and biases fixed mutations in diploids.Semantic proximity Read ↗

Environment by environment interactions (ExE) differ across genetic backgrounds (ExExG)Semantic proximity Read ↗

Environment-by-Environment Interactions Differ Across Genetic Backgrounds.Semantic proximity Read ↗

The limit to evolutionary rescue depends on ploidy in yeast exposed to nystatin.Semantic proximity Read ↗

Changes in the distribution of fitness effects and adaptive mutational spectra following a single first step towards adaptation.Semantic proximity Read ↗

Molecular and cellular bases of adaptation to a changing environment in microorganisms.Semantic proximity Read ↗

The evolution of drug resistance in clinical isolates of Candida albicans.Semantic proximity Read ↗

Clonal Heterogeneity Influences the Fate of New Adaptive Mutations.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.