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Article

Conditional expression of oncogenic K-ras from its endogenous promoter induces a myeloproliferative disease.

The Journal of clinical investigation - 1 Feb 2004

Chan Iris T, Kutok Jeffery L, Williams Ifor R, Cohen Sarah, Kelly Lauren, Shigematsu Hirokazu, Johnson Leisa, Akashi Koichi, Tuveson David A, Jacks Tyler, Gilliland D Gary

Abstract excerpt

Oncogenic ras alleles are among the most common mutations found in patients with acute myeloid leukemia (AML). Previously, the role of oncogenic ras in cancer was assessed in model systems overexpressing oncogenic ras from heterologous promoters. However, there is increasing evidence that subtle...

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Identifiers

PMID: 14966562
DOI: 10.1172/JCI20476
PMCID: PMC338267

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-14966562-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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Conditional expression of oncogenic K-ras from its endogenous promoter induces a myeloproliferative disease.PMID 14966562Read ↗

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