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Polymorphisms of thymidylate synthase in the 5'- and 3'-untranslated regions and gastric cancer.

Digestive diseases and sciences - 1 Jul 2009

Zhuang Wen, Wu Xiao-Ting, Zhou Yong, Liu Guan-Jian, Wu Tai-Xiang, Yao Xun, Du Liang, Wei Mao-Ling

Abstract excerpt

Studies investigating the association of polymorphisms in the 5'-untranslated regions (5'UTR) and 3'-untranslated regions (3'UTR) of thymidylate synthase with gastric cancer susceptibility and sensitivity to fluoropyrimidine-based chemotherapy report conflicting results. The objective of this study was to quantitatively summarize the evidence for such a relationship. This meta-analysis included ten studies, which...

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PMID: 18989779
DOI: 10.1007/s10620-008-0511-8

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