Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Spreading of amyloid-β peptides via neuritic cell-to-cell transfer is dependent on insufficient cellular clearance

9 Jan 2014

Abstract excerpt

The spreading of pathology through neuronal pathways is likely to be the cause of the progressive cognitive loss observed in Alzheimer's disease (AD) and other neurodegenerative diseases. We have recently shown the propagation of AD pathology via cell-to-cell transfer of oligomeric amyloid beta (Aβ) residues 1-42 (oAβ1-42) using our donor-acceptor 3-D co-culture model. We now show that different Aβ-isoforms...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alzheimer's disease research and treatments
Share to Nerve injury and regeneration
Share to Neuroinflammation and Neurodegeneration Mechanisms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 24412310
DOI: 10.1016/j.nbd.2013.12.019

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Spreading of amyloid-β peptides via neuritic cell-to-cell transfer is dependent on insufficient cellular clearancePMID 24412310Read ↗

Fate and propagation of endogenously formed Tau aggregates in neuronal cellsSemantic proximity Read ↗

The Fate of Tau Aggregates Between Clearance and TransmissionSemantic proximity Read ↗

The cell biology of prion-like spread of protein aggregates: mechanisms and implication in neurodegenerationSemantic proximity Read ↗

A deadly spread: cellular mechanisms of α-synuclein transfer.Semantic proximity Read ↗

From nucleation to widespread propagation: A prion-like concept for ALSSemantic proximity Read ↗

The uptake of tau amyloid fibrils is facilitated by the cellular prion protein and hampers prion propagation in cultured cellsSemantic proximity Read ↗

Visualization of prion-like transfer in Huntington's disease models.Semantic proximity Read ↗

Amyloid-β42/40 ratio drives tau pathology in 3D human neural cell culture models of Alzheimer's disease.Semantic proximity Read ↗

Heterotypic seeding of Tau fibrillization by pre-aggregated Abeta provides potent seeds for prion-like seeding and propagation of Tau-pathology in vivo.Semantic proximity Read ↗

Neuron-to-neuron wild-type Tau protein transfer through a trans-synaptic mechanism: relevance to sporadic tauopathies.Semantic proximity Read ↗

Prion-like seeding and nucleation of intracellular amyloid-βSemantic proximity Read ↗

Transfer of polyglutamine aggregates in neuronal cells occurs in tunneling nanotubesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.