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Roles of Hsp104 and trehalose in solubilisation of mutant huntingtin in heat shocked Saccharomyces cerevisiae cells.

Biochimica et biophysica acta - 1 Apr 2014

Saleh Aliabbas A, Gune Uma S, Chaudhary Rajeev Kumar, Turakhiya Ankit P, Roy Ipsita

Abstract excerpt

Inhibition of huntingtin aggregation, either in the nucleus and/or in the cytosol, has been identified as a major strategy to ameliorate the symptoms of Huntington's disease. Chaperones and other protein stabilisers would thus be key players in ensuring the correct folding of the amyloidogenic protein and its expression in the soluble form. By transient activation of the global heat stress response in...

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PMID: 24412307
DOI: 10.1016/j.bbamcr.2014.01.004

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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