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Article

Cellular toxicity of mutant SOD1 protein is linked to an easily soluble, non-aggregated form in vitro.

Neurobiology of disease - 1 Jan 2013

Brotherton Terrell E, Li Yingjie, Glass Jonathan D

Abstract excerpt

Mutations in superoxide dismutase 1 (SOD1) are found in approximately 20% of patients with familial amyotrophic lateral sclerosis. The propensity of mutant SOD1 to form aggregates in pathologically affected cells (i.e. motor neurons) has implicated these poorly soluble protein aggregates and/or their misfolded soluble precursors as being instrumental to the disease process. We investigated the relative solubility...

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Identifiers

PMID: 22926189
DOI: 10.1016/j.nbd.2012.08.010
PMCID: PMC3549044

Genes

SOD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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