Article
Hsp104 as a key modulator of prion-mediated oxidative stress in Saccharomyces cerevisiae.
The Biochemical journal - 1 Sept 2013
Singh Kuljit, Saleh Aliabbas A, Bhadra Ankan K, Roy Ipsita
Abstract excerpt
Maintenance of cellular redox homoeostasis forms an important part of the cellular defence mechanism and continued cell viability. Despite extensive studies, the role of the chaperone Hsp104 (heat-shock protein of 102 kDa) in propagation of misfolded protein aggregates in the cell and generation of oxidative stress remains poorly understood. Expression of RNQ1-RFP in Saccharomyces cerevisiae cells led to the...
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