Article
Identification of a permissible HLA mismatch in hematopoietic stem cell transplantation.
Blood - 20 Feb 2014
Fernandez-Viña Marcelo A, Wang Tao, Lee Stephanie J, Haagenson Michael, Aljurf Mahmoud, Askar Medhat, Battiwalla Minoo, Baxter-Lowe Lee-Ann, Gajewski James, Jakubowski Ann A, Marino Susana, Oudshoorn Machteld, Marsh Steven G E, Petersdorf Effie W, Schultz Kirk, Turner E Victoria, Waller Edmund K, Woolfrey Ann, Umejiego John, Spellman Stephen R, Setterholm Michelle
Abstract excerpt
In subjects mismatched in the HLA alleles C*03:03/C*03:04 no allogeneic cytotoxic T-lymphocyte responses are detected in vitro. Hematopoietic stem cell transplantation (HSCT) with unrelated donors (UDs) showed no association between the HLA-C allele mismatches (CAMMs) and adverse outcomes; antigen mismatches at this and mismatches other HLA loci are deleterious. The absence of effect of the CAMM may have resulted...
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