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Article

Major-Histocompatibility-Complex Class I Alleles and Antigens in Hematopoietic-Cell Transplantation

20 Dec 2001

Abstract excerpt

BACKGROUND: Successful engraftment of hematopoietic stem cells from unrelated donors is influenced by disparities between the donor and recipient for HLA-A, B, and C alleles. Disparities between HLA sequence polymorphisms that are serologically detectable are termed antigen mismatches, whereas those that can be identified only by DNA-based typing methods are termed allele mismatches. Whether both kinds of...

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PMID: 11752355
DOI: 10.1056/nejmoa011826

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