Article
Vascular endothelial growth factor polymorphisms affect gene expression and tumor aggressiveness in patients with breast cancer.
Molecular medicine reports - 1 Mar 2014
Sa-Nguanraksa Doonyapat, Kooptiwut Suwattanee, Chuangsuwanich Tuenjai, Pongpruttipan Tawatchai, Malasit Prida, O-Charoenrat Pornchai
Abstract excerpt
Vascular endothelial growth factor (VEGF) is one of the key modulators of angiogenesis. The highly polymorphic promoter and 5' untranslated region of VEGF have been associated with susceptibility to and aggressiveness of several types of cancer. To examine the functional role of VEGF polymorphism...
Topics
- Adolescent
- Adult
- Alleles
- Breast Neoplasms
- Female
- Gene Expression Regulation, Neoplastic
- Genes, Reporter
- Genotype
- Haplotypes
- Humans
- Lymphatic Metastasis
- MCF-7 Cells
- Mutagenesis, Site-Directed
- Polymorphism, Genetic
- Promoter Regions, Genetic
- RNA, Messenger
- Vascular Endothelial Growth Factor A
- Young Adult