Vascular endothelial growth factor ‑634G/C polymorphism is associated with increased breast cancer risk and aggressiveness.

doi:10.3892/mmr.2013.1607

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Vascular endothelial growth factor ‑634G/C polymorphism is associated with increased breast cancer risk and aggressiveness.

Molecular medicine reports - 1 Oct 2013

Sa-Nguanraksa Doonyapat, Chuangsuwanich Tuenjai, Pongpruttipan Tawatchai, Kummalue Tanawan, Rojananin Supakorn, Ratanawichhitrasin Adune, Prasarttong-Osoth Poramaporn, Chuthatisith Suebwong, Pisarnturakit Pongthep, Aeumrithaicharoenchok Waraporn, Rushatamukayanunt Pradit, Lohsiriwat Visnu, Boonsripitayanon Mongkol, Malasit Prida, O-Charoenrat Pornchai

Abstract excerpt

Polymorphisms in the promoter and 5' untranslated region of vascular endothelial growth factor (VEGF) have been associated with VEGF levels. To investigate the role of VEGF polymorphisms in breast cancer, the VEGF ‑2578C/A, ‑1498C/T, ‑1154G/A and ‑634G/C polymorphisms were genotyped in 483 breast cancer patients and 524 healthy controls. VEGF mRNA levels in breast cancer tissue were determined using...

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PMID: 23904001
DOI: 10.3892/mmr.2013.1607

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