Article
Vascular endothelial growth factor polymorphisms in relation to breast cancer development and prognosis.
Clinical cancer research : an official journal of the American Association for Cancer Research - 15 May 2005
Jin Qianren, Hemminki Kari, Enquist Kerstin, Lenner Per, Grzybowska Ewa, Klaes Rüdiger, Henriksson Roger, Chen Bowang, Pamula Jolanta, Pekala Wioletta, Zientek Helena, Rogozinska-Szczepka Jadwiga, Utracka-Hutka Beata, Hallmans Göran, Försti Asta
Abstract excerpt
PURPOSE: Angiogenesis is a necessary step in tumor growth and metastasis. Vascular endothelial growth factor (VEGF) is a major mediator of breast cancer angiogenesis. Therefore, we investigated the association of polymorphisms in the VEGF gene with breast cancer risk and prognostic characteristics of the tumors in a large case-control study. EXPERIMENTAL DESIGN: We examined three polymorphisms in the VEGF gene...
Topics
- Adult
- Aged
- Breast Neoplasms
- Case-Control Studies
- Female
- Genotype
- Humans
- Middle Aged
- Neoplasm Metastasis
- Neoplasm Staging