Article
Vascular endothelial growth factor polymorphisms in relation to breast cancer development and prognosis.
Clinical cancer research : an official journal of the American Association for Cancer Research - 15 May 2005
Jin Qianren, Hemminki Kari, Enquist Kerstin, Lenner Per, Grzybowska Ewa, Klaes Rüdiger, Henriksson Roger, Chen Bowang, Pamula Jolanta, Pekala Wioletta, Zientek Helena, Rogozinska-Szczepka Jadwiga, Utracka-Hutka Beata, Hallmans Göran, Försti Asta
Abstract excerpt
PURPOSE: Angiogenesis is a necessary step in tumor growth and metastasis. Vascular endothelial growth factor (VEGF) is a major mediator of breast cancer angiogenesis. Therefore, we investigated the association of polymorphisms in the VEGF gene with breast cancer risk and prognostic characteristics of the tumors in a large case-control study. EXPERIMENTAL DESIGN: We examined three polymorphisms in the VEGF gene...
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