Association of vascular endothelial growth factor and vascular endothelial growth factor receptor-2 genetic polymorphisms with outcome in a trial of paclitaxel compared with paclitaxel plus bevacizumab in advanced breast cancer: ECOG 2100.

doi:10.1200/JCO.2008.16.1612

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Article

Association of vascular endothelial growth factor and vascular endothelial growth factor receptor-2 genetic polymorphisms with outcome in a trial of paclitaxel compared with paclitaxel plus bevacizumab in advanced breast cancer: ECOG 2100.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 1 Oct 2008

Schneider Bryan P, Wang Molin, Radovich Milan, Sledge George W, Badve Sunil, Thor Ann, Flockhart David A, Hancock Bradley, Davidson Nancy, Gralow Julie, Dickler Maura, Perez Edith A, Cobleigh Melody, Shenkier Tamara, Edgerton Susan, Miller Kathy D

Abstract excerpt

PURPOSE: No biomarkers have been identified to predict outcome with the use of an antiangiogenesis agent for cancer. Vascular endothelial growth factor (VEGF) genetic variability has been associated with altered risk of breast cancer and variable promoter activity. Therefore, we evaluated the ass...

Topics

Antibodies, Monoclonal
Antibodies, Monoclonal, Humanized
Antineoplastic Combined Chemotherapy Protocols
Bevacizumab
Breast Neoplasms
Female
Genotype
Haplotypes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Hypertension

Paclitaxel

Polymorphism, Single Nucleotide

Proportional Hazards Models

Retrospective Studies

Statistics, Nonparametric

Survival Rate

Vascular Endothelial Growth Factor A

Vascular Endothelial Growth Factor Receptor-2

Source

Open in PubMed Open full text

Identifiers

PMID: 18824714
DOI: 10.1200/JCO.2008.16.1612
PMCID: PMC2653128

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-18824714-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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