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Article

Association between 318C/T polymorphism of the CTLA-4 gene and systemic lupus erythematosus in Iranian patients.

International journal of rheumatic diseases - 1 Dec 2017

Shojaa Mahdieh, Aghaie Mehrdad, Amoli Mahsa, Javid Naemeh, Shakeri Fatemeh, Khashayar Patricia, Tabarraei Alijan, Keshtkar Abbas A, Joshaghani Hamid R, Kouroshnia Arghavan, Qorbani Mostafa, Mahmoudi Faranak, Mohebbi Ramin, Ranjbarpour Neda

Abstract excerpt

BACKGROUND: Cytotoxic T lymphocyte-associated antigen-4 (CTLA-4) is an important negative regulator of T-cell response. It is a functional candidate gene connected with susceptibility to systemic lupus erythematosus (SLE). We analyzed the role of -318C/T polymorphism in the promoter region of the CTLA-4 gene in Iranian patients suffering from SLE. METHODS: A total of 180 SLE patients and 304 healthy ethnically...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 24400885
DOI: 10.1111/1756-185X.12275

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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