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Association of CTLA4 exon-1 polymorphism with the tumor necrosis factor-α in the risk of systemic lupus erythematosus among South Indians.

Human immunology - 1 Feb 2016

Katkam Shiva Krishna, Kumaraswami Konda, Rupasree Yedluri, Thishya Kalluri, Rajasekhar Liza, Kutala Vijay Kumar

Abstract excerpt

Cytotoxic T lymphocyte associated-antigen (CTLA4) is a potential negative regulatory molecule of T-cells and associated with several autoimmune diseases. Several reports from different ethnic groups showed that the polymorphisms of the CTLA4 gene have been associated with autoimmune diseases including SLE. Therefore, we aimed to investigate the +49 A/G polymorphism in South Indian SLE patients and its association...

Topics

Adolescent
Adult
CTLA-4 Antigen
Cytokines
Exons
Gene Frequency
Genetic Association Studies
Genetic Predisposition to Disease
Genotype
Humans
India

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Lupus Erythematosus, Systemic

Polymorphism, Genetic

Risk

Tumor Necrosis Factor-alpha

Young Adult

Source

Identifiers

PMID: 26582004
DOI: 10.1016/j.humimm.2015.11.002

Genes

CTLA4
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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