Article
No evidence of association between CTLA-4 polymorphisms and systemic lupus erythematosus in Iranian patients.
International journal of rheumatic diseases - 1 Dec 2013
Shojaa Mahdieh, Javid Naemeh, Amoli Mahsa, Shakeri Fatemeh, Samaei Nader M, Aghaie Mehrdad, Khashayar Patricia, Livani Sedigheh
Abstract excerpt
AIM: Cytotoxic T lymphocyte-associated antigen-4 (CTLA-4) is an important negative regulator of T-cell responses. CTLA-4 polymorphisms have been confirmed to be associated with several autoimmune diseases such as systemic lupus erythematosus (SLE). We analyzed the role of CTLA-4 polymorphism at positions -1661 and -1722 in Iranian patients suffering from SLE. METHODS: One hundred and eighty SLE patients and 304...
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