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Article

Nucleotide excision repair is a potential therapeutic target in multiple myeloma

7 Jun 2017

Abstract excerpt

Despite the development of novel drugs, alkylating agents remain an important component of therapy in multiple myeloma (MM). DNA repair processes contribute towards sensitivity to alkylating agents and therefore we here evaluate the role of nucleotide excision repair (NER), which is involved in the removal of bulky adducts and DNA crosslinks in MM. We first evaluated NER activity using a novel functional assay...

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PMID: 28588253
DOI: 10.1038/leu.2017.182

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