Article
Global regulation of mRNA translation and stability in the early Drosophila embryo by the Smaug RNA-binding protein.
Genome biology - 7 Jan 2014
Chen Linan, Dumelie Jason G, Li Xiao, Cheng Matthew Hk, Yang Zhiyong, Laver John D, Siddiqui Najeeb U, Westwood J Timothy, Morris Quaid, Lipshitz Howard D, Smibert Craig A
Abstract excerpt
BACKGROUND: Smaug is an RNA-binding protein that induces the degradation and represses the translation of mRNAs in the early Drosophila embryo. Smaug has two identified direct target mRNAs that it differentially regulates: nanos and Hsp83. Smaug represses the translation of nanos mRNA but has only a modest effect on its stability, whereas it destabilizes Hsp83 mRNA but has no detectable effect on Hsp83...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.