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Article

Drosophila maternal Hsp83 mRNA destabilization is directed by multiple SMAUG recognition elements in the open reading frame.

Molecular and cellular biology - 1 Nov 2008

Semotok Jennifer L, Luo Hua, Cooperstock Ramona L, Karaiskakis Angelo, Vari Heli K, Smibert Craig A, Lipshitz Howard D

Abstract excerpt

SMAUG (SMG) is an RNA-binding protein that functions as a key component of a transcript degradation pathway that eliminates maternal mRNAs in the bulk cytoplasm of activated Drosophila melanogaster eggs. We previously showed that SMG destabilizes maternal Hsp83 mRNA by recruiting the CCR4-NOT deadenylase to trigger decay; however, the cis-acting elements through which this was accomplished were unknown. Here we...

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Identifiers

PMID: 18794360
DOI: 10.1128/MCB.00037-08
PMCID: PMC2573300

Genes

CCR4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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