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Article

The ability of TRIM3 to induce growth arrest depends on RING-dependent E3 ligase activity.

The Biochemical journal - 15 Mar 2014

Raheja Radhika, Liu Yuhui, Hukkelhoven Ellen, Yeh Nancy, Koff Andrew

Abstract excerpt

Mutation of the TRIM (tripartite motif)-NHL family members brat and mei-P26 perturb the differentiation of transit-amplifying progenitor cells resulting in tumour-like phenotypes. The NHL (named after the NCL1, HT2A and LIN41 repeat) domain is essential for their growth suppressive activity, and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cyclin-Dependent Kinase Inhibitor p21

Share to Protein Structure, Tertiary

Share to Ubiquitin-Conjugating Enzymes

Share to Ubiquitin-Protein Ligases

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Source

Open in PubMed Open full text

Identifiers

PMID: 24393003
DOI: 10.1042/BJ20131288
PMCID: PMC4404499

Genes

TRIM3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24393003-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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