Article
The ability of TRIM3 to induce growth arrest depends on RING-dependent E3 ligase activity.
The Biochemical journal - 15 Mar 2014
Raheja Radhika, Liu Yuhui, Hukkelhoven Ellen, Yeh Nancy, Koff Andrew
Abstract excerpt
Mutation of the TRIM (tripartite motif)-NHL family members brat and mei-P26 perturb the differentiation of transit-amplifying progenitor cells resulting in tumour-like phenotypes. The NHL (named after the NCL1, HT2A and LIN41 repeat) domain is essential for their growth suppressive activity, and they can induce cell-cycle exit in a RING-independent manner. TRIM3 is the only bona fide tumour suppressor in the...
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