Article
TRIM3, a tumor suppressor linked to regulation of p21(Waf1/Cip1.).
Oncogene - 16 Jan 2014
Liu Y, Raheja R, Yeh N, Ciznadija D, Pedraza A M, Ozawa T, Hukkelhoven E, Erdjument-Bromage H, Tempst P, Gauthier N P, Brennan C, Holland E C, Koff A
Abstract excerpt
The TRIM family of genes is largely studied because of their roles in development, differentiation and host cell antiviral defenses; however, roles in cancer biology are emerging. Loss of heterozygosity of the TRIM3 locus in ∼20% of human glioblastomas raised the possibility that this NHL-domain...
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