Article

Structural and functional characterisation of class VI TRIM E3 ligases

2020-01-01

Abstract excerpt

Ubiquitination is a widespread post-translational modification integral to all cellular processes. Substrate ubiquitination is catalysed by a multi-enzyme cascade consisting of E1 activating enzymes, E2 conjugating enzymes, and E3 ligase enzymes. The Tripartite Motif (TRIM) family represents the largest family of RING-type E3 ligases in humans. TRIM proteins share a conserved N-terminal domain architecture consist...

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Literature Corpus work: f0d54914-de1c-5c91-9514-f2ab34579471
DOI: 10.25560/79306

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