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Article

A role for FACT in repopulation of nucleosomes at inducible genes.

PloS one - 1 Jan 2014

Voth Warren P, Takahata Shinya, Nishikawa Joy L, Metcalfe Benjamin M, Näär Anders M, Stillman David J

Abstract excerpt

Xenobiotic drugs induce Pleiotropic Drug Resistance (PDR) genes via the orthologous Pdr1/Pdr3 transcription activators. We previously identified the Mediator transcription co-activator complex as a key target of Pdr1 orthologs and demonstrated that Pdr1 interacts directly with the Gal11/Med15 subunit of the Mediator complex. Based on an interaction between Pdr1 and the FACT complex, we show that strains with...

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Share to Antifungal Agents
Share to Chromatin Assembly and Disassembly

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Drug Resistance, Fungal

Share to Fungal Proteins

Share to Gene Expression Regulation, Fungal

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Share to Transcription, Genetic

Source

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Identifiers

PMID: 24392107
DOI: 10.1371/journal.pone.0084092
PMCID: PMC3879260

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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