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Article

A unique hybrid characteristic having both pro- and anti-inflammatory phenotype transformed by repetitive low-dose lipopolysaccharide in C8-B4 microglia.

Scientific reports - 2 Jun 2020

Mizobuchi Haruka, Yamamoto Kazushi, Tsutsui Shoko, Yamashita Masafumi, Nakata Yoko, Inagawa Hiroyuki, Kohchi Chie, Soma Gen-Ichiro

Abstract excerpt

Although lipopolysaccharide (LPS) is regarded as an inducer of inflammation, previous studies have suggested that repetitive low-dose LPS has neuroprotective effects via immunomodulation of microglia, resident macrophages of brain. However, microglia transformed by the stimulus of repetitive low-dose LPS (REPELL-microglia) are not well characterized, whereas microglia transformed by repetitive high-dose LPS are...

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Identifiers

PMID: 32488176
DOI: 10.1038/s41598-020-65998-8
PMCID: PMC7265460

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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